1-Chloroacetyl-2,6-bis(3-fluorophenyl)piperidin-4-one
نویسندگان
چکیده
In the title compound C(19)H(16)ClF(2)NO(2), the piperidone ring adopts a twist-boat conformation with the two out-of-plane atoms deviating by 0.544 (1) and 0.511 (1) Å from the plane through the remaining atoms in the ring. Sterically favoured non-H-atom C⋯O inter-molecular contacts are observed in the structure, within a 3.00 Å range. The crystal packing is stabilized by C-H⋯O and C-H⋯F hydrogen bonds and an inter-molecular π-π inter-action [centroid-centroid separation of 3.783 (1) Å]. Alternating C-H⋯O and C-H⋯F inter-molecular inter-actions generate chains running along the a axis, while a centrosymmetric R(2) (2)(16) ring involving C-H⋯O inter-actions is formed centred at (1/2, 1/2, 0).
منابع مشابه
1-Chloroacetyl-2,6-bis(2-chlorophenyl)-3,5-dimethylpiperidin-4-one
In the title compound, C(21)H(20)Cl(3)NO(2), the piperidin-4-one ring adopts a boat conformation. The two 2-chloro-phenyl groups are approximately perpendicular to each other, making a dihedral angle of 74.07 (8)°.
متن کامل1-Chloroacetyl-2,6-bis(2-chlorophenyl)-3,5-dimethylpiperidin-4-one oxime
In the title compound, C(21)H(21)Cl(3)N(2)O(2), the piperidine ring adopts a distorted boat conformation. One of the chloro-phenyl rings is almost perpendicular to the best plane through piperidine ring, making a dihedral angle of 88.7 (1)°, whereas the other ring is twisted by 71.8 (1)°. The crystal packing is stabilized by inter-molecular C-H⋯O, C-H⋯Cl and O-H⋯O inter-actions.
متن کامل3-Isopropyl-2,6-bis(4-methoxyphenyl)piperidin-4-one
In the title compound, C(22)H(27)NO(3), the piperidine ring adopts a slightly distorted chair conformation. The dihedral angle between the two aromatic rings is 60.4 (1)°. In the crystal, the amino group forms a rather long N-H⋯O contact to a methoxy O atom. There are also C-H⋯O interactions present.
متن کامل1-Chloroacetyl-2,6-bis(2-methoxyphenyl)-3,5-dimethylpiperidin-4-one
The piperidone ring in the title compound, C(23)H(26)ClNO(4), adopts a boat conformation with its two out-of-plane C atoms deviating by 0.597 (2) and 0.630 (2) Å from the least-squares plane of the rest of atoms in the ring. The two aromatic rings are roughly perpendicular to each other, making a dihedral angle of 75.1 (1)°, and a C-H⋯π intra-molecular inter-action is observed. The crystal pack...
متن کاملCrystal structure of 1-(2-chloroacetyl)-2,6-bis(4-fluorophenyl)-3,3-dimethylpiperidin-4-one
In the title mol-ecule, C21H20ClF2NO2, the piperidine ring adopts a slightly distorted boat conformation. The two benzene rings form a dihedral angle of 87.43 (1)°. A weak intra-molecular C-H⋯π inter-action is observed. In the crystal, weak C-H⋯O hydrogen bonds and weak C-H⋯π inter-actions connect the mol-ecules, forming a three-dimensional network.
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عنوان ژورنال:
دوره 65 شماره
صفحات -
تاریخ انتشار 2009